Beta© 2026 Adaptrex, LLC
Beta© 2026 Adaptrex, LLC
Federal grant · project grant (b)
Clearbot: a System for Fully Automated, High-throughput Tissue Clearing and Immunostaining - Summary Tissue Clearing Is a Powerful Technique That Renders Large Biological Samples Optically Transparent and Allows 3D Visualization of Wide-brain Molecular Anatomy. to Help Disseminate This Technology, Translucence Biosystems Developed a Mesoscale Imaging System™ and, Using Previous Sbir Nih Support, an Analytical Software Package for Advanced Analysis of Brain Samples, 3TKTM. While Complete Solutions Exist for Imaging and Analysis of Cleared Samples, No Complete Solution Exists for the Highly Labor Intensive and Error Prone Tissue Clearing Process. Here Translucence Biosystems Introduce Clearbot™, an Automated System for Sample Clearing and Immunostaining That Will Complement Previous Translucence Devices and Complete a Pipeline for Reliable Brain- Wide Molecular Anatomy of Intact Rodent and Human Tissues. in This Phase I Proposal, Translucence Biosystems Will Build a Prototype of Clearbot™ and Demonstrate Automated Brain Tissue Clearing for Whole-brain Analysis. Specific Aims: Aim 1: Assemble and Evaluate a Clearbot Prototype: the Basic Functionality of the Prototype Developed by an Engineering Consultant Will Be Evaluated for Functionality, Robustness, Energy Consumption, and Overall Reliability. Aim 2: Evaluate the Utility of Clearbot for Automated Clearing and Immunostaining of Intact Brains: Quality and Repeatability of Tissue Clearing Will Be Evaluated Using the Prototype Assembled in Aim 1. Multiple Mouse Brains Will Be Cleared and Immunostained With Clearbot and Benchmarked to Manual Processing Done in Parallel. This Phase I Project Will Demonstrate the Feasibility of Developing an Automated Device That Is Comparable to or Better Than Manual Clearing. Following Success of This Phase I Feasibility Testing, Future Developments Will Advance the Prototype to a Flexible, Commercial-grade System With a Robust and Simple User-interface, Helping Researchers Apply This Game-changing Technology to Their Research Questions.
Committed
$459,655
Paid out
$415.5K
90%
Committed, not yet paid
$44.1K
10%
Loading…
Everything here is this single award's whole record — signed, amended, paid — not a fiscal-year slice. The by-year charts elsewhere split an award across the years it was committed; this page keeps it whole.
Committed is what the government has legally promised on this award so far. Contracts can also carry a ceiling — the maximum if every option is exercised. Unspent ceiling is headroom, not money owed.
The cash actually disbursed against this award. The gap from committed is the disbursement pipeline: promised, not yet cashed.
Each transaction is a signing event — an action that created or changed the award, dated the day it was signed — not a payment. Negative amounts are real: money de-committed at closeout or renegotiation.
One bar, the award’s whole arithmetic: paid out, then committed, not yet paid, then unspent ceiling.