Advancedcpr Solutions LLC

Head Up CPR and Aortic Occlusion to Improve Survival After Refractory Cardiac Arrest - Abstract in 2024 There Will Be Nearly 800,000 Cardiac Arrest Cases in the Us Alone. of Those Only About 50,000 Will Have a Full Recovery. More Than 750,000 Patients Will Have No Hope for Meaningful Survival. That Is Because There Is No Currently Demonstrable Effective Treatment for Refractory (r)-ca Patients, the Enormous Subgroup of Patients Who Invariably Die Annually From This Leading Cause of Death. Depending Upon the Presenting Rhythm, Ca Becomes Refractory to Current Interventions, Herein Defined as a <2% Survival, <10 Minutes After Starting Conventional (C) CPR. This Application Is Focused on a Better Treatment for Patients With Ca Refractory to Current Management Strategies, Regardless of the Initial Rhythm Presentation. Patients in R-ca Cannot Be Resuscitated With C-CPR, Defibrillation for a Shockable Rhythm, and Vasopressor Therapy, Such as Epinephrine, Fluids, and Anti-arrhythmic Drugs. for Over a Half Century We Have Failed to Effectively Treat R-ca: We Have Not Known How. Occasionally Transcutaneous Cardiac Pacing, Ecmo And/or Double Sequential Defibrillation Can Be Used With Some Benefit for the Very Small Percentage of Patients That Remain in Refractory Ventricular Fibrillation (R-VF). However, in General These Treatment Strategies Rarely Work for R-ca, Especially in Patients With a Non-shockable Presenting Rhythm That Comprise 75-85% of All Ca Cases. However, the Applicants Recently Observed That the Addition of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) to Automated Head Up Position (AHUP) CPR Resulted in a Synergistic and Remarkable Improvement in Coronary and Cerebral Perfusion Pressures After More Than 30 Minutes of Ahup-cpr in Pigs. This Discovery Suggests That Reboa + Ahup CPR May Provide More Definitive Treatment for R-ca or, at a Minimum, a Bridge to More Definitive Therapy. Based Upon These New Findings, the Applicants Intend to Test the Hypothesis That the Addition of Reboa to Ahup-cpr for R- Ca Will Significantly Improve Brain and Vital Organ Blood Flow and Increase the Likelihood of Neurologically- Favorable Survival in a Well-established Pre-clinical Model.