Wellsim Biomedical Technologies Inc

Multi-omics Profiling of Individual Exosomes for Their Origin-tracing, Biomarker Discovery, and Biological Function Characterization - Project Summary / Abstract Exosomes, the Small Extracellular Vesicles (30-200 NM), Are Highly Heterogeneous in Biofluids. However, Traditional Bulk-level Analysis Approaches Fail to Represent Their Individual Variations. a Technique for Multi-omics Profiling of Exosomes at Single-particle Resolution Is of Great Interest to the Exosome Research Field, But Has Yet to Be Developed. Wellsim Proposes to Develop and Validate a Method for Multi-omics Profiling of Individual Exosomes Based on Our Exosome Isolation System (exodus), a Droplet-based Microfluidic Device (exoseq), and Next-generation Sequencing (NGS). Our Proposed Technique Will Be the First Integrative Proteomic and Transcriptomic Profiling of Exosomes at the Single-particle Level, Offering High-resolution Multi-dimensional Biological Insights for Exosome Study and Application.