Zebra Analytix Inc

Micro Breath Biomarker Analyzer - Project Summary This Phase I Sbir Will Develop a Microfabricated Breath Biomarker Analyzer. There Is an Unmet Need for Easy-to-use, Cost-effective, Miniature Devices for Rapid, Specific, and Sensitive Analysis of Breath Biomarkers, Especially Volatile Organic Compounds (vocs). the Proposed Analyzer Is Built on High-performance Mems (microelectromechanical Systems) Gas Chromatography (GC) Columns. a Preliminary Study Demonstrated the Mems Column’s High Separation Efficiency and Speed, and Developed a Functional Prototype of One-dimensional Micro GC With a Single Mems Column. in This Phase I Study, the Mems Column Technology Will Be Adopted to Develop a Microfabricated Comprehensive Two-dimensional GC (micro Gcxgc), So as to Significantly Improve the Separation Power of Micro GC and Address the Need for Breath Voc Biomarker/profile Analysis. Phase I Specific Aims Are to Create a Prototype Sampling Device for Extraction and Preconcentration of Breath Vocs, Demonstrate Gcxgc With Two Mems Columns Having Orthogonal Selectivity for Breath Vocs on a Benchtop GC, and Create a Proof-of-concept Prototype of the Proposed Mems Column Based Breath Voc Analyzer. the Proposed Product Aims to Address the Unmet Need for Point-of-need Breath Biomarker Studies. It Is Expected to Have Wide Applications for Personal Exposure Assessment and Health Status Monitoring.