Nytricx, Inc.

Nitric Oxide Releasing Ultra-slippery Antibacterial Surfaces for Urological Catheter Applications - Abstract Urinary Catheters Are One of the Most Widely Used Medical Devices in a Hospital Setting and Are Expected to Only Increase in Growth Due to the Aging Population. Out of All the Various Biomedical Devices That Are Frequently Used in a Clinical Setting, Urinary Catheters Are Associated With the Largest Portion of Medical Complications Related to Infection. Catheter Associated Urinary Tract Infections (CAUTIS) Account for Nearly 40% of All Healthcare Associated Infections (HAIS) and Can Lead to Extended Hospital Stays for Patients Which in Turn Leads to Higher Healthcare Costs. to Overcome This Risk of Infection, a Catheter Surface That Is Able to Prevent Bacterial Adhesion and Biofilm Formation While Simultaneously Eliminating Planktonic Bacteria Present in the Vicinity Is Highly Desirable. However, No Long-term Catheter Solution Has Been Able to Accomplish This Goal. Nytricx, Inc. Has Developed Proprietary Methods and Know-how Developing Anti-infective Nitric Oxide (NO) Releasing Interfaces Capable of Effectively Eliminating a Wide Variety of Bacterial Strains While Being Able to Elicit No Cytotoxic Response From Mammalian Cell Lines. Nytricx, Inc. Has Also Demonstrated That the Liquid-infusion of Silicone Oil to Create a Super Slippery Surface Is Able to Prevent the Adhesion of Proteins and Bacteria and Thus Eliminate Biofilms. a Synergistic Antimicrobial Response Is Achieved by Combining Liquid-infused Strategy and No Releasing Polymers (linorel). the Overall Objective of This Phase I Sbir Application Is to Create a Long-term Highly Antimicrobial Urinary Catheter Through a Combination of Impregnating Foley Catheters With a No Donor, S-nitroso-n- Acetylpenicillamine (snap), With a Liquid-infused Silicone Oil Interface and to Evaluate Commercialization Feasibility in Terms of Mechanical and Biological Properties.