Federal grant · project grant (b)
An Enzyme-based Assay for the Detection of Acetaldehyde-protein Adducts - Abstract Chronic Alcohol Consumption Is a Significant Issue Worldwide Which Can Lead to Addiction and Damage Throughout the Body. the First Step in Alcohol Metabolism Is Its Conversion Into Acetaldehyde, Which Is a Highly Reactive and Toxic Molecule. the Formation of Acetaldehyde Adducts With Protein and Dna Is a Primary Mechanism of Ethanol Toxicity. Acetaldehyde Adducts Are a Direct Biomarker for Alcohol Abuse. We Intend to Develop a Facile and Rapid Enzyme-based Assay for Measuring Acetaldehyde-protein Adducts to Assess Alcohol Use and Alcohol-related Health Consequences.
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