Brimrose Technology Corp

Continuous Photoacoustic Monitoring of Neonatal Stroke in Intensive Care Unit - Project Summary/abstract Neonatal Encephalopathy Can Arise From Fetal Hypoxia-ischemia During Labor, Chronic Uteroplacental Inflammation, and Large Cerebral Artery Embolization Primarily Arising From Dislodgement of a Placental Thrombus. Because of Overlapping Clinical Presentation, Differential Diagnosis Is Often Delayed Until Seizures Develop and Mri Can Be Safely Performed, a Time at Which Most Neuroprotectants Are Ineffective. Whereas Hypothermia Is Approved for Use Within 6 Hours of Birth for Hypoxia-ischemia, No Treatments Have Been Approved for Perinatal Arterial Ischemic Stroke Because of the Difficulty of Definitive Diagnosis Required for Clinical Trial Stratification at Birth. With an Estimated Incidence of 17-93 Per 100,000 Live Births, the Incidence of Stroke in the Perinatal Period Rivals the Incidence of Stroke in Adults (17-23 Per 100,000). Therefore, a Device That Could Rapidly and Reliably Identify an Area of Focal Cerebral Ischemia Soon After Birth Would Have a Major Impact by Enabling the Testing of Neuroprotectants at an Early Therapeutic Time Window That Would Maximize Efficacy. the Brimrose Technology Corporation, Partnering With Johns Hopkins University, Propose a Photoacoustic Helmet (PAH) Device That Can Be Safely Deployed at the Bedside in the Neonatal Intensive Care Unit to 1) Continuously Monitor and Rapidly Identify At-risk Neonates, Shortly After Birth, Rapidly Allowing Them to Be Triaged to Therapy; 2) Monitor the Progress of Therapy; and 3) Provide Prognostic Information to the Parents of Newborns at Risk for Life-long Brain Injury. the Pa Imaging Mechanism Is a Purely Hybrid Mechanism, Providing Rich Optical Absorbance Contrast of Tissue Oxy- and Deoxyhemoglobin Through Intact Scalp and Skull. a Proof-of-concept of Detecting Decreased Tissue Oxyhemoglobin in a 1 Cm-induced Experimental Stroke Has Been Demonstrated With Standard Laboratory Pa Laser Light Source and Clinical Ultrasound Detector. Our Goal Is to Incorporate Safer Light-emitting Diodes (LEDS) and More Sensitive Ultrasound Detectors Configured in a Neonatal Helmet to Localize Cortical Regions of Low Oxygenation in the Newborn. in the Proposed Phase-i STTR, We Will Develop Fundamental Hardware and Software Components for Effective Integration. Aim 1 - Software for Safe Pah Imaging at High Contrast Resolution, Including Deep Neural Network and Optimal Spectral Unmixing Techniques to Enable a Safe and High-speed Led-based Pah System. Aim 2 - Hardware for Modular Pah System, Including a Fiber-coupled Brimrose Ultra-sensitive Multi- Bounce Laser Microphone and Optimal Modular Unit Design for a Pah Imaging at High Spatial-temporal-spectral Resolution Through Intact Scalp and Skull. Aim 3 - Framework for Modular Pah System Integration, Enabling a Robust Integration of Modular Units in a Pah System With Rigid-body Tag Registration Using Optical Tracking, in Which Different Neonatal Head Shapes and Need for Different Imaging Specifications Can Be Accommodated. the Phase-i Milestone Is Detection of the Full Blood O2 Saturation Range at <10 MM Full-width-half-maximum in the Transverse Plane and 5 MM Sensing Depth Through Ex Vivo Neonatal Piglet Skull + Scalp Sample With an Integrated Set of Hardware and Software Packages, Allowing Preclinical Validation Studies to Proceed in Phase Ii.