Texas Biomedical Research Institute

Interdisciplinary Nexgen TB Research Advancement Center (in-trac) - Texas Biomed In-trac Overall Abstract the Interdisciplinary Nexgen TB Research Advancement Center (in-trac) at Texas Biomedical Research Institute (texas Biomed) Will Attract the Next Generation of Diverse Researchers to the Tuberculosis (TB) Research Field, and Develop Them Into Independent Researchers With Multi-disciplinary Skills and Real-world Experience of Clinical TB. the Product of In-trac Will Be Researchers That Choose to Work on Some of the Most Challenging and Relevant Translational Problems in TB, and That Work Across Academic Disciplines and Within a Framework of Highly Collaborative Research. This Will Be Achieved Through 6 Interrelated Cores. Administrative Core: the Central Hub of In-trac Management and Oversight, With Responsibility for Administrative and Scientific Leadership; Coordinating Communication Between Cores, Researchers and Nih/niaid Program Staff and Providing an Organizational Structure to Optimize Multidisciplinary Collaborations and Interactions Between the Cores and Among a Diverse Cohort of In-trac Participants. Development Core: Oversight of All Career Development Programming and Courses, Tailoring the Research and Clinical Experiences, Both Intern and Externships, to Each Individual In-trac Participant, and Management of the In-trac Pilot Grant Program. Biosafety & Biocontainment Core: Extending the Required Biosafety Training to a Personalized Curriculum Including Theoretical and Hands-on Biocontainment Training, Understanding the Mechanical and Regulatory Requirements of a BSL3/ABSL3, Coaching on How to Develop Biosafety Protocols, and Working Through Risk Assessments From the Perspective of a Biosafety Officer. Research Imaging Core: Providing Theoretical and Hands-on Training From Single Cell Imaging (confocal Microscopy, Cytometry, Live Cell Imaging, Single Cell Rnaseq) Through to Whole Body Imaging in Mice (IVIS) and Non-human Primates (NHP) (pet/ct) Within Large, Fully Outfitted BSL3/ABSL3 Facilities. Animal Model Core: Implementing a Training Program to Introduce All In-trac Participants to the Regulatory Requirements for Working With Rodents and NHPS, How to Develop a Robust Experimental Protocol, How to Write an Iacuc Protocol, and Hands-on Animal Handling and Experimental Procedures. Clinical Research & Patient Care Core: Introducing In-trac Participants to TB Patient Care at the Only Free-standing TB Hospital in the Us (texas Center of Infectious Diseases) That Manages Some of the Most Challenging Cases of TB Nationally. Partnering With This Will Be a Clinical Research Experience at the Us- Mexico Border, to Experience TB Studies in Under-served and Under-resourced Communities.