Vivoverse, LLC

Awards Issued Prior to January 20, 2025, Were Funded Under Previous Administrations and May Not Reflect the Priorities and Policies of the Current Administration. the Field of Food Science Is Growing Rapidly to Develop New Substances With Added Nutritional Values and Discover New Therapeutic Benefits Such as a Source of Natural Antioxidants, Health-promoting Materials, Nutraceuticals, and Potential Functional Foods. Identifying and Quantifying Nutritional Benefits in Food Ingredients and Evaluating Their Biological Activities Are Essential to Gauge Their Efficacy and Safe Applications. the Traditional Method of Nutritional Profiles Using Mass-spectrometry Measurements Provides Knowledge of the Active Molecules. Still, It Cannot Provide Any Information on Their Biological Activities That Require in Vivo Models. Efficacy Studies With Higher Mammals Are Costly, Highly Regulated, and Take Several Years to Complete. to Overcome These Challenges, We Propose to Develop a C. Elegans-based Alternative to Animal Testing Strategy to Assess the Health Benefits of Ingredients Available in Food, Herbal Preparations, Plants, and Derived Products. C. Elegans Can Provide Ethical Testing While Preserving Many Signaling Pathways Governed by Orthologous Genes and Crispr-assisted Gene Editing That Aid in Capturing Toxicity and Health Benefits in Amulti-organ Intact Organism. Despite These Advantages, Current-day C. Elegans-based Assays Suffer From Low-throughput or Low-resolution Imaging Technologies.our High-resolution Imaging Platform With an Automated Image Analysis Pipeline Will Facilitate Rapid Detection of Multiple Phenotypes Related to Lipid Storage, Stress Level, Gut Health, Growth, and Reproductive Health. We Will Test the Robustness of Our Assay and Validate Using Six Food Ingredients in Consultation With Our Industry and Academia Collaborators. in Addition, Our Assay Will Also Help Identify Adverse Effects, Allowing Our Customers to Define Safe Dose Limits for Their Ingredients. Our Technology Can Help Determine the Health Benefits of Novel Food Products and New Materials, Helping Usda Food Science and Nutrition to Meet the Long-term Goals of Producing Novel Food Products That Can Improve Health and Avoid Adverse Effects on Human Health Outcomes.